Prob is v1.4 was prob ordered before many had boards so it may just end up what it is.
Repeating myself in a vane attempt to hopefully Radxa might make a rethink on layout but that decision might of already been made.
I don’t think you can fit to any format as SBC SoC offerings are often very unique but having all I/O on one side of a board makes it very easy to fit any case bigger than board dimensions and Radxa just need to create either stick on or screw down I/O cut outs of simple low cost sheet metal or even plastic.
I liked the PicoItx because the I/O where on one side and the rest with cable extensions could be also, the actual format of PicoItx meant nothing really as for a start it isn’t but there is near no PicoItx product anyway.
I guess if the dsi/csi port convertors where in the shop and compact, relative low cost then no probs as then the extra functionality of the pins is also not lost, they add fiddly complexity, but would work.