Ok following situation turned my Orion O6 into an neat ITX build with a case, an ATX 550 Watts PSU from Chieftec with an Radeon Pro 8100, did some setups and testing today and when done shut down the system but did not unplug it.
One or two hours later I got a certain electronics smell in my nose (soldering tin) first thought something with the PSU (had this happen before) until I noticed a pretty noticeable heat coming from the case openend it up and the GPU was burning hot.
After it cooled down a bit i turned it on and a loud complain from the GPU (overheat beep) it went into emergency mode until it further cooled down, now everything seems fine again and hopfully no damage.
So system does not seem to turn off the GPU and it keeps running and heating up with no fan, really bad, when running it stays cold, but turned off it will heat up over time.
Clearly needs a firmware correction, will keep an eye on this, to help.